Department of Psychiatry, Psychotherapy, and Psychosomatics – Preclinical Lab for translational research into affective disorders

 

Methods

  1. Automated behavioural testing of emotional, motivational and cognitive processes in mice
  2. Environmental stressors
  3. Adeno-associated viral vectors for stress factor over-expression e.g. Corticotrophin releasing hormone; Pro-inflammatory cytokines
  4. Genetically-modified mice: Serotonin transporter (slc6a4) knockout; TNF receptor 1 (Tnfrsf1a) knockout; Potassium channel tetramerization domain-containing protein 12 (Kctd12) knockout
  5. Stereotactic surgery
  6. In vivo microdialysis
  7. Neuropsychopharmacology
  8. Biomarker analysis in brain, cerebrospinal fluid, blood and faeces (ELISA)
  9. High performance liquid chromatography and tandem mass spectrometry (in collaboration)
  10. Neuroanatomy (Histology, in situ hybridization, immunohistochemistry) (in collaboration)
  11. Quantitative molecular genetics and epigenetics (DNA methylation, Transcriptome microarray expression profiling) (in collaboration)
  12. Magnetic resonance imaging of neural activity (in collaboration)